Includes bibliographical references and index.
|Statement||edited by Wolfram Siede, Yoke Wah Kow, Paul W. Doetsch.|
|Contributions||Siede, Wolfram., Kow, Yoke Wah., Doetsch, Paul W.|
|LC Classifications||QH467 .D154 2006|
|The Physical Object|
|Pagination||xxii, 845 p. :|
|Number of Pages||845|
"Covering a wide array of topics from bacteria to human cells, the book summarizes recent developments in DNA damage repair and recognition while providing timely reviews on the molecular mechanisms employed by cells to distinguish between damaged and undamaged sites and stimulate the appropriate repair pathways."--Jacket. Stands as the most comprehensive guide to the subject-covering every essential topic related to DNA damage identification and repair. Covering a wide array of topics from bacteria to human cells, this book summarizes recent developments in DNA damage repair and recognition while providing timely reviews on the molecular mechanisms employeCited by: It is a sensitive and rapid method for the detection of DNA damage. A detailed description of this technique was presented in Methods in Molecular Biology by different authors , , . Briefly, cells placed in low-melting agarose on the surface of microscope slides are subjected to electrophoresis after the action of a damaging by: 1. DNA repair and replication pathways converge on a common final step in which the continuity of the repaired DNA strand is restored by DNA ligase, an enzyme that converts nicks into phosphodiester bonds. We aim to elucidate the structures and catalytic mechanisms of DNA ligases from diverse taxa, especially the basis for nick sensing.
Mechanisms of Damage Recognition: Theoretical Considerations. UV Damage and Other Bulky DNA-adducts. Non-bulky Base Damage. Mismatch Repair. Replicational Bypass of DNA Lesions. DNA Strand Breaks. Perception of DNA Damage for Initiating Regulatory Responses: Responsibility: [edited by] Wolfram Siede, Yoke Wah Kow, Paul W. Doetsch. Cell , The recognition of DNA damage Jackson 25 This paper shows that S. cerevisiae tell mutants have shortened telomeres and display heightened chromosomal instability, and it reports that Tell is a kDa protein that falls into the PI 3-kinase by: A DNA-damage recognition sensor triggers a signal transduction cascade and downstream factors direct G1 and G2 arrest in concert with the proteins operationally responsible for the repair process. Although there are at least six discrete repair mechanisms, within five of them there are numerous multiprotein complexes comprising all the Author: Ainsley Weston, Curtis C. Harris. This book summarizes existing knowledge on how these DNA damage processing pathways are selectively targeted to defective sites in the mammalian genome. It discusses the biological, clinical and toxicological implications of DNA damage recognition in a comprehensive : Hanspeter Naegeli.
The large ATM (ataxia telangiectasia mutated) and ATR (AT and Rad3-related) kinases have come into focus as early, central participants in the DNA damage recognition and signaling processes (Fig. 2 and Fig. 6). 3, 38 41 These functionally related proteins phosphorylate a multitude of substrates and appear to exist in vivo in high molecular Cited by: 1. Buy DNA damage; effects on DNA structure and protein recognition. Ed. by Susan S. Wallace, Bennett Van Houten and Yoke Wah Kow. (Annals of the New York Academy of Sciences, Vol. ) on FREE SHIPPING on qualified orders. DNA repair is a collection of processes by which a cell recognizes and corrects damage to the DNA molecules that encode its genome. In human cells, both normal metabolic functions and environmental factors such as radiation can cause DNA damage, causing in as many as 1 million individual molecular lesions per cell per day. Many of these lesions lead to structural damage . Types. Damage to DNA that occurs naturally can result from metabolic or hydrolytic processes. Metabolism releases compounds that damage DNA including reactive oxygen species, reactive nitrogen species, reactive carbonyl species, lipid peroxidation products and alkylating agents, among others, while hydrolysis cleaves chemical bonds in DNA. Naturally occurring oxidative .